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By Takaomi Comings Saido

Beta-secretase M. Citron Alpha-secretases S. Ishiura ADAM 10/alpha secretase and presenilins/gamma secretase in APP processing and notch signaling D. Hartmann Gamma-secretase and presenilin M. Wolfe Biochemistry of gamma-secretase (tentative identify) S. Sinha Presenilin and intracellular protein delivery Degradation of Abeta by way of neprilysin T.C. Saido Degradation of Abeta by means of endothelin-converting enzyme C. Eckman Degradation of Abeta through insulin-degrading enzyme Lipid raft and Abeta metabolism T. Golde Lipid raft and Abeta accumulation M. Morishima-Kawashima and Y. Ihara Transport-dependent clearance of Abeta B. Zlokovic Abeta vaccination C. Lemere

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Lichtenthaler S, Seed B. The aspartyl protease BACE regulates the shedding of p-selectin glycoprotein ligand-1. Neurobiol Aging 2002; 23:S175-S176. 44. Holsinger RMD, McLean CA, Masters CL et al. BACE and β-secretase product CTFβ are increased in sporadic Alzheimer’s disease brain. Neurobiol Aging 2002; 23:S177. 45. Shen Y, Yang L-B, Yang X-L et al. Alteration of beta secretase (BACE) expression in sporadic Alzheimer’s brains. Neurobiol Aging 2002; 23:S190. 46. Fukamoto H, Cheung B, Hyman BT et al.

Mol Cell Biol 2002; 22:1537-1544. 18. Wolfe MS, Xia W, Ostaszewski BL et al. Two transmembrane aspartates in presenilin-1 required for presenilin proteolysis and γ–secretase activity. Nature 1999; 398:513-517. 19. Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nature Rev Mol Cell Biol 2000; 1:217-224. 20. Small DH. The role of presenilins in γ-secretase activity: catalyst or cofactor? J Neurochem 2001; 76:1612-1614. 21. Checler F. The multiple paradoxes of presenilins. J Neurochem 2001; 76:1621-1627.

46. Lim GP, Chu T, Yang F et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001; 21(21):8370-8377. 47. Funato H, Yoshimura M, Kusui K et al. Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer’s disease. Am J Pathol 1998; 152:1633–1640. 48. Funato H, Enya M, Yoshimura M et al. Presence of sodium dodecyl sulfate-stable amyloid β-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation.

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