Download BioMEMS and Biomedical Nanotechnology: Volume I Biological by Jun Li, M. Meyyappan (auth.), Mauro Ferrari Ph.D., Abraham PDF

By Jun Li, M. Meyyappan (auth.), Mauro Ferrari Ph.D., Abraham P. Lee, L. James Lee (eds.)

Abe Lee has been engaged on micro/ and nanotechnology for biomedical and biotech purposes on the grounds that 1992. His contemporary learn specializes in the advance of built-in micro and nano fluidic chip processors for the subsequent purposes: point-of-care diagnostics, "smart" nanomedicine for early detection and remedy, stem telephone biology and therapeutics, the synthesis of novel and natural fabrics, and biosensors to realize environmental and terrorism threats. He has over 30 peer reviewed guides and over 30 issued US patents. i'm additionally topic editor for the magazine of Microelectromechanical platforms and member of the overseas Advisory Editorial Board for the Lab on a Chip journal.

Jim Lee's study curiosity contains BioMEMS/NEMS, and polymer micro/nanotechnology. within the final four years, he has over 20 refereed magazine courses, 2 e-book chapters, and five patents in those parts. he's now best an NSF Nanoscale technology and Engineering middle for cheap Nanoengineering of Polymer Biomedical units at OSU.

Professor Mauro Ferrari is a pioneer within the fields of bioMEMS and biomedical nanotechnology. As a number one educational, a devoted entrepreneur, and a imaginative and prescient setter for the Nation's most excellent Federal courses in nanomedicine, he brings a three-fold vantage standpoint to his roles as Editor-in-Chief for this paintings. Dr. Ferrari has authored or co-authored over one hundred fifty clinical guides, 6 books, and over 20 US and

International patents. Dr. Ferrari can also be Editor-in-Chief of Biomedical Microdevices and sequence editor of the hot Springer sequence on rising Biomedical Technologies.

Several deepest area businesses originated from his laboratories on the Ohio kingdom collage and the college of California at Berkeley through the years. On a Federal project as particular

Expert in Nanotechnology and Eminent pupil, he has supplied the medical management for the improvement of the Alliance for melanoma Nanotechnology of the nationwide melanoma Institute, the world-largest scientific nanotechnology operation so far. Dr. Ferrari proficient in mathematical physics in Italy, bought his Master's and Ph.D. in Mechanical

Engineering at Berkeley, attended scientific college on the Ohio kingdom collage, and served in school positions in fabrics technological know-how and Engineering, and Civil and Environmental Engineering in Berkeley, the place he was once first tenured. At Ohio nation he presently serves as Professor of inner medication, department of Hematology and Oncology, as Edgar Hendrickson Professor of Biomedical Engineering, and as Professor of Mechanical Engineering. he's affiliate Director of the Dorothy M. Davis

Heart and Lung examine Institute, and the University's affiliate vice chairman for healthiness technological know-how, know-how and Commercialization.

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In microspheres composed of surface-eroding polymers, drug is released primarily at the surface as the polymer breaks down around it. Erosion of such polymers usually proceeds at a constant velocity [66]. If the drug of interest is homogeneously dispersed throughout a microsphere, the largest rate of release will occur at the beginning. As time proceeds, the surface area of the sphere and the release rate decrease asymptotically. MICROSPHERES FOR DRUG DELIVERY 21 Polymer molecular weight can affect polymer degradation and drug release rates.

The low-molecular-weight polymer resulted in porous, quickly releasing microspheres while the high-molecular-weight formulation resulted in dense microspheres and produced a sigmoidal release profile. By mixing microspheres comprising the two polymers, release rates could be tailored, and the resulting profiles were linear combinations of those resulting from individual microspheres. Bezemer et al. produced linear lysozyme release over 25 days from PEG-PBT microspheres having a bimodal size distribution dominated by 50-µm and 110-µm particles (in essence a combination of two sizes) [21].

T. Ng, J. Han, and M. Meyyappan. Nanotechnology, 15: 9, 2004. V. Staros. Biochemistry, 21: 3950, 1982. Y. Miki, J. Swensen, D. A. Futreal, K. Harshman, S. Tavtigian, Q. Liu, C. M. Bennett and W. Ding. Science, 266: 66, 1994. F. C. H. Thorp. J. Phys. Chem. B, 103: 10718, 1999. D. H. Thorp. Interface, 11 (4): 30, 2002. 2 Microspheres for Drug Delivery Kyekyoon “Kevin” Kim and Daniel W. 1. INTRODUCTION With advances in biotechnology, genomics, and combinatorial chemistry, a wide variety of new, more potent and specific therapeutics are being created.

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