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Coronary Artery Restenosis: The Intervention Stage of CAD Revascularization procedures allow the reopening or bypassing of significant coronary artery stenoses but themselves trigger a response-to-injury, leading to restenosis. Negative remodeling, including elastic recoil, is an important element for restenosis with percutanenous transluminal balloon angioplasty (PTCA) as is neointima formation for in-stent restenosis. As yet another distinction from primary atherosclerosis, the restenotic lesions after PTCA and stenting are rich in extracellular matrix (collagen and matrix proteoglycans) rather than cells [2].

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