Chapter 1 Chairman's commencing comments (pages 1–2): R. W. E. Watts
Chapter 2 Purine and Pyrimidine Metabolism: Pathways, Pitfalls and Perturbations (pages 3–21): J. Frank Henderson, Jeffrey okay. Lowe and Jerzy Barankiewicz
Chapter three Microbial types and Regulatory components within the keep watch over of Purine Metabolism (pages 23–41): Josepha S. Gots, Charles E. Benson, Bjarne Jochimsen and ok. R. Koduri
Chapter four Molecular Nature of Enzyme law in Purine Biosynthesis (pages 43–64): James B. Wyngaarden and Edward W. Holmes
Chapter five Genetic Heterogeneity on the Locus for Hypoxanthine?Guanine Phosphoribosyltransferase (pages 65–81): William L. Nyhan
Chapter 6 components within the Pathogenesis of the mind harm and Anaemia within the Lesch?Nyhan Syndrome (pages 83–96): R.O. Mckeran
Chapter 7 Hypoxanthine?Guanine Phosphoribosyltransferase job in person Erythrocytes: Autoradiographic reviews in Heter Ozygotes (pages 97–104): B. T. Emmerson, R. B. Gordon and L. A. Johnson
Chapter eight Purine Biosynthesis in Mutant Mammalian Cells (pages 105–126): Gabrielle H. Reem
Chapter nine Purine and Pyrimidine Nucleotides in a few Mutant Human Lymphoblasts (pages 127–142): G. Nuki, okay. Astrini, D. Brenton, M. Cruikshank, J. Lever and J. E. Seegmiller
Chapter 10 Superactivity of Phosphoribosylpyrophosphate Synthetase, because of suggestions Resistance, inflicting Purine Overproduction and Gout (pages 143–164): Oded Sperling, Pnina Boer, Sara Brosh, Esther Zoref and Andre de Vries
Chapter eleven nutritional suggestions law of Purine and Pyrimidine Biosynthesis in guy (pages 165–178): N. Zollner and W. Grobner
Chapter 12 Implications of issues of Purine Metabolism for the Kidney and the Urinary Tract (pages 179–206): Andre de Vries and Oded Sperling
Chapter thirteen The position of de novo Purine Synthesis in Lymphocyte Transformation (pages 207–224): A. C. Allison, T. Hovi, R. W. E. Watts and A. D. B. Webster
Chapter 14 Purine Metabolism and keep an eye on of phone Proliferation (pages 225–248): Tapani Hovi, Tapani Hovi, Anthony C. Allison, Kari O. Raivio and Antti Vaheri
Chapter 15 The impression of Adenosine on Lymphoid phone Proliferation and Antibody Formation (pages 249–276): J. Edwin Seegmiller, T. Watanabe and Max H. Schreier
Chapter sixteen Characterization of Human Adenosine Deaminase (pages 277–293): William N. Kelley, Peter E. Daddona and Martin B. van der Weyden
Chapter 17 The Purinergic Nerve speculation (pages 295–314): Geoffrey Burnstock
Chapter 18 Inherited Metabolic illness: customers for the long run in either uncomplicated and scientific study (pages 315–355): R. W. E. Watts
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Additional resources for Ciba Foundation Symposium 48 - Purine and Pyrimidine Metabolism
Two structural gene products (purF) and (purG) have been implicated as possible regulatory elements for the use of guanosine, and a role for glutamine in the induction of GMP reductase has been revealed. Abstract Microbial models have been particularly useful in elucidating the molecular basis of regulation and genetic control of various metabolic pathways (see review by Gots & Benson 1974). Control at the level of gene expression and enzyme formation involves various regulatory elements, of which the basic functional unit is the operon.
Enzyme activity correlates directly with the amount of amidophosphoribosyltransferase present in small form (Fig. 3). Glutamine has no influence on these interchanges. These findings suggest a model in which the form of the human enzyme with molecular weight 270000 is inactive and the one with molecular weight 133 000 is the catalytic species (Holmes et al. 19738). 46 J. B. WYNGAARDEN AND E. W. 1. Conversion of small form of human amidophosphoribosyltransferaseinto large form in the presence of the purine ribonucleotide AMP.
B. & SEEGMILLER, J. E. (1977) Purine synthesis and excretion in human lymphoblast mutants deficient in adenosine kinase and adenine phosphoribosyltransferase. Adv. Exp. Med. , RAZIN,A. & MAGER, J. (1969) Regulation of the synthesis of 5-phosphoribosyl1-pyrophosphate in intact red blood cells and in cell-free preparations. Biochim. Biophys. Acta 184, 64-16 LAJTHA,L. & VANE,J. R. (1958) Dependence of bone marrow cells on liver for purine supply. ) 182, 191-192 LERNER,M. H. & LOWY,B. A. (1974) The formation of adenosine in rabbit liver and its possible role as a direct precursor of erythrocyte adenine nucleotides.