Download Clinical and Genetic Aspects of Epilepsy by Z. Afawi PDF

By Z. Afawi

Show description

Read Online or Download Clinical and Genetic Aspects of Epilepsy PDF

Similar neuropsychology books

Plasticity Theory

This self-contained textual content for complex undergraduate and graduate scholars is dedicated to classical quasistatic difficulties of rate-independent plasticity thought. It discusses the finite aspect process for either viscoplastic and rate-independent plastic solids, as well as huge deformation plasticity numerical equipment for rate-based formulations and hyperelastic tools.

Introduction to neuropsychology

Now in a considerably revised moment variation, this remarkable textual content provides scholars a pretty good grounding in medical and experimental neuropsychology. the writer is a number one authority whose enticing writing type and thorough but concise insurance of mind localization, anatomy, and their hyperlinks to cognitive functionality make the publication excellent for undergraduate or graduate use.

Routledge Handbook of Communication Disorders

The Routledge guide of communique problems offers an replace on key matters and examine within the medical program of the speech, language and listening to sciences in either kids and adults. concentrating on parts of state of the art learn, this guide showcases what we all know approximately communique problems, and their review and therapy.

Neurology for the Speech-Language Pathologist

The concise, easy-to-understand Neurology for the Speech-Language Pathologist, sixth version offers scholars and clinicians with a realistic consultant for the research and figuring out of neurology in speech-language pathology (SLP). Correlated with medical syndromes and illnesses noticeable in SLP, it provides a high-quality realizing of the apprehensive process, together with: improvement of the worried procedure, association of the mind, protecting mechanisms, descending motor and ascending sensory pathways, and cranial nerves.

Additional info for Clinical and Genetic Aspects of Epilepsy

Example text

2005). , 2007). In addition to P-gp, data indicate that BCRP plays a significant role in drug efflux at the blood-brain barrier. , 2007). However, little information is available on the extent to which BCRP contributes to AED resistance and if Pgp and BCRP work in concert in AED efflux from the brain. , 2005). More studies are needed to unequivocally clarify the role of BCRP, especially in conjunction with P-gp, in AED-resistant epilepsy. Only little information is available on the multidrug resistance proteins (Mrps) in epilepsy.

Nemeroff and Crisley made a critical discovery in 1975 when they found that glutamate is involved in seizure induction and increases cerebrovascular permeability in rats (Nemeroff & Crisley, 1975). , 1977). In 1989, Clarke and Gabrielsen demonstrated seizure-induced bloodbrain barrier leakage in humans using computed tomography (Clarke & Gabrielsen, 1989). In 1995, Tishler et al. , 1995). , 2008). , 2005). Today, the role of some of these transporters in epilepsy is still unclear. , 2007). , 2007).

1995). The findings by Tishler et al. , 2002) and it was suggested that this phenomenon could prevent AEDs from entering the brain and cause AED resistance. , 2003). , 2007). They demonstrated that phenytoin permeation was 10-fold lower in endothelial cells from AED-resistant patients compared to purchased human endothelial cells. Although this comparison is flawed, inhibiting P-gp increased phenytoin permeation in the AED-resistant cells. , 2007). Using a drug-resistant epilepsy rat model, Potschka et al.

Download PDF sample

Rated 4.60 of 5 – based on 18 votes