By Amir Pelleg, Luiz Belardinelli
225 pages, 25 figures, four tables, paperback
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Extra info for Effects of Extracellular Adenosine and ATP on Cardiomyocytes
The further exploration of A2BAR signal transduction, both in regard to molecular mechanisms and physiologic significance, would be greatly aided by the development of subtype selective ligands. STRUCTURAL DETERMINANTS OF AR SIGNAL TRANSDUCTION In that several cells such as cardiac myocytes contain multiple ARs, the ultimate response of the cell upon either accumulation of endogenously-released adenosine or the administration of its analogs, is dictated predominantly by the relative affinity of the specific AR subtypes for the agonist, as well as the selective coupling of a particular receptor subtype to a specific G protein and that G protein to effector.
Sexl V, Mancusi G, Höller C et al. Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem 1997; 272:5792-5799. Adenosine Receptor-Mediated Signal Transduction 37 77. Hirano D, Aoki Y, Ogasawara H et al. Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells. Biochem J 1996; 316:81-86. 78. Lupica CR, Cass WA, Zahniser NR et al. Effects of the selective adenosine A2 receptor agonist CGS21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum.
30. Koch WJ, Hawes BE, Inglese J et al. Cellular expression of the carboxyl terminus of a G-protein coupled receptor kinase attenuates βγmediated signaling. J Biol Chem 1994; 269:6193-6197. 31. Smrcka AV, Sternweis PC. Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C β by G protein α and βγ subunits. J Biol Chem 1993; 267:9667-9674. 32. Cohen MV, Downey JM. Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease. Annu Rev Med 1996; 47:21-29.