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By P. A. Miescher, A. Gerebtzoff, P. H. Lambert (auth.), P. Frick, G.-A. von Harnack, G. A. Martini, A. Prader, R. Schoen, H. P. Wolff (eds.)

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C) Increased Nephrotoxicity. . . Dosage Adaptation in Renal Insufficiency . 1. Method Based on Dosage Intervals . 2. Method Based on the Reduction of Doses II. Individual Drug Behavior in Renal Insufficiency . Antibiotics . . . . Other Antibacterial Agents Antiparasitic Drugs . . Fungicides . . . . Drugs for Tuberculosis. Digitalis and Drugs used in Cardiology . Anti-Arrhythmics . Anticoagulants . . Diuretics . . . . Antihypertensive Drugs. General Anesthetics . Neuromuscular Blocking Agents.

Prevalence of renal insufficiency among 19 patients with vestibular destruction after small doses of streptomycin, compared with 81 patients whose lesions appeared after higher doses The nephrologist faces enormous difficulties caused by the change in behavior of drugs in patients suffering from severe renal insufficiency or subjected to chronic hemodialysis. But this problem concerns all physicians, since frequently even a modest reduction of renal function may cause involuntary overdosage in prolonged therapy.

W. CONN per gram of tissue, while no renin activity was detectable in the adjacent kidney*. Were it not for the high levels of renin activity in the removed tumor tissue, it would have been impossible to accept this case as one of renin-secreting tumor, since the high renin values found in plasma might have been the result of compression of the right renal arterial tree. Case 2 was that of a four year old male, admitted with a blood pressure of 200/130, a six month history of polyuria and a large, right-sided abdominal mass.

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