By V Craig Jordan
This quantity offers the evolution of the authors' rules approximately estrogen motion and its modulation via a brand new staff of gear referred to as SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs -- tamoxifen and raloxifene -- are recognized to have stored the lives of thousands of ladies all over the world and superior the healthiness of thousands extra. Estrogen is the imperative hormone of women's wellbeing and fitness and copy. The booklet is a trip via forty years of discovery and good fortune in advancing women's health and wellbeing, with the chance of more desirable innovation via medicinal chemistry for the long run.
Readership: Clinicians, organic college, educated sufferers, scientists and scholars in biology and medication, healthcare and doctors, breast melanoma survivors.
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Extra info for Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health : Progress and Promise
Only teams of people make discoveries and progress. The successive tamoxifen teams built on the scientific contributions of others who came before and the result was to advance health around the world by controlling breast cancer and increasing breast cancer survivorship for millions of women. REFERENCES 1. Toft D, Gorski J. (1966) A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization. Proc Natl Acad Sci USA 55(6): 1574–1581. 2. Toft D, Shyamala G, Gorski J.
In: Estrogen Receptor in Human Breast Cancer, eds. McGuire WL, Carbone PP, Volmer EP. New York: Raven, pp. 1–7. 32. Jensen EV, Jordan VC. (2003) The estrogen receptor: a model for molecular medicine. The Dorothy P. Landon AACR Prize for Translational Research. Clin Cancer Res 9:1980–1989. 33. Baumler E. (1984) Paul Ehrlich, Scientist for Life. New York: Holmes & Meier. 34. Huggins C, Grand LC, Brillantes, FP. (1961) Mammary cancer induced by a single feeding of polynuclear hydrocarbons and their suppression.
Brodie and coworkers50,51 advanced knowledge of the specific targeting of the CYP19 aromatase enzyme with the identification and subsequent development of 4-hydroxyandrostenedione52 as the first practical suicide inhibitor of the aromatase enzyme (Fig. 4). Incidentally, the pivotal work with both tamoxifen and 4-hydroxyandrostenedione (Figs. g. anastrozole (Fig. indd 11 4/17/2013 2:49:34 PM b1487 Estrogen Action, Selective Estrogen Receptor 12 Figure 4. | V. C. Jordan Structures of inhibitors of estrogen and androgen biosynthesis.